It is confirmed that radioactive material was subject to illegal trafficking from mafia and terrorist groups, which constitutes a serious threat to the population and could dramatically endanger its health. These groups are using standard unprotected transports and infrastructures – trucks, train, harbors or airports – for material transits. The NANTISTA project is a 42 month collaborative public-private partnership project that aims to develop a low-cost solution that can be deployed at a large scale by states to detect and identify radiological threats. It proposes a unified nuclear threat detection platform in order to reach the full potential of low-cost and robust solid organic scintillators designed in a previous Agence Nationale de la Recherche (ANR) project. This is enabled by using recent neuromorphic signal processing. It aims at designing very low-cost systems for homeland security applications that would enable large scale monitoring and securing good transit in Europe.